26 papers
This study demonstrates that integrating prehospital point-of-care blood gas analysis into physician-staffed emergency medical services significantly increases safe ambulatory treatment rates and improves patient selection for hospital admission through better risk stratification.
Although emergency clinicians reviewed social drivers of health data more frequently during encounters with patients having opioid use disorder, this engagement was rare overall, did not predict the prescription of medications for opioid use disorder, and failed to address persistent racial and ethnic treatment disparities.
This study demonstrates that a multimodal deep learning model utilizing ECG-derived spectrograms significantly outperforms established clinical scores and vital sign-based models in predicting the deterioration of patients with suspected sepsis within 48 hours of emergency department admission.
This integrated clinical and network pharmacology study demonstrates that adjunctive Shenfu Injection significantly reduces 28-day mortality and accelerates recovery in septic shock patients, likely through a multi-target mechanism modulating inflammatory and cellular signaling pathways such as TNF, PI3K-Akt, and IL-17.
This six-year follow-up study demonstrates that a nurse-led triage tool successfully redirecting low-acuity emergency department patients to a co-located general practitioner cooperative remains a safe, efficient, and sustainable intervention in routine practice without dedicated post-trial support.
This paper presents a clinically oriented deep learning framework utilizing a high-performing ResNeXt-50 model and Grad-CAM++ interpretability to accurately classify venomous versus non-venomous Indian snakes, aiming to assist primary care providers in rural settings with timely triage and treatment decisions.
This statewide cross-sectional study of Massachusetts public high schools reveals that while most institutions offer some CPR instruction, student training coverage remains limited and is significantly lower in Title I schools, highlighting a critical need for equitable policies to improve cardiac emergency preparedness.
A retrospective study of 342 patients at Long Island Jewish Medical Center found that while certain demographic and social factors appeared to correlate with follow-up rates after referrals to community-based organizations, none reached statistical significance, suggesting the need for larger studies to better understand and address social determinants of health in improving patient engagement.
This prospective observational study demonstrates that the longitudinal kinetics of specific inflammatory biomarkers, particularly IL6, IL1RN, TNFRSF1A, IL8, and PCT, are significantly associated with sepsis diagnosis, organ dysfunction severity, and in-hospital mortality in emergency department patients, suggesting their potential utility in improving prognosis and risk stratification.
This paper describes the development of the AMEND implementation package, a theory- and evidence-based intervention utilizing a person-based approach to support the transition from salbutamol to Maintenance and Reliever Therapy (MART) for adults discharged from the Emergency Department with uncontrolled asthma.
The REVIVE-PEEP trial is a multicenter, triple-blind, randomized controlled study designed to determine whether applying 8 cm H2O of positive end-expiratory pressure (PEEP) during manual ventilation for out-of-hospital cardiac arrest improves neurological outcomes at hospital discharge compared to zero end-expiratory pressure.
This updated meta-analysis of six randomized controlled trials involving over 4,000 critically ill patients found no significant difference in 28-day mortality between etomidate and ketamine for emergency intubation, though ketamine was associated with a higher incidence of post-intubation hypotension.
This prospective multicentre cohort study in India demonstrates that both simple, physiology-based prediction models (particularly GAP) and clinician gestalt-based triage exhibit excellent discrimination and calibration for predicting 30-day mortality in adult trauma patients, providing a practical foundation for improving trauma triage systems.
This study demonstrates that while both a structured phenotype and a large language model effectively identify opioid use disorder in emergency department records, the LLM achieves significantly higher specificity and positive predictive value, suggesting it could reduce false-positive alerts in clinical workflows.
This study utilized group-based trajectory modeling on MIMIC-IV and external validation data to identify three distinct red blood cell distribution width (RDW) trajectories in sepsis patients, revealing that a fluctuating-rapid decrease pattern is independently associated with significantly higher 30-day and 90-day mortality compared to other patterns.
This retrospective study of 1,053 acute coronary syndrome patients demonstrates that eosinophil levels and novel eosinophil-derived leukocyte ratios, particularly SIII and SV, are strong predictors of disease severity comparable to established markers, highlighting their potential value for rapid risk stratification in emergency settings.
This double-blind randomized controlled pilot study evaluated the feasibility of a larger trial investigating vitamin C's analgesic effects in acute musculoskeletal injury patients, confirming recruitment and adherence feasibility while noting high electronic diary retention rates and inconclusive pain reduction results due to wide confidence intervals.
This prospective, international multicenter study validates that the ESC 0/3h-algorithm using the novel hs-cTnI-VITROS assay safely rules out NSTEMI with high sensitivity, while demonstrating that substituting the HEART score for the GRACE score significantly improves rule-out efficacy without compromising safety.
This observational study of over 41,000 low-acuity emergency department visits in the southeastern United States, guided by the Andersen Behavioral Model, found that predisposing and enabling factors—particularly older age, unemployment or disability, mental health diagnoses, and lack of established primary care—were the primary drivers of EMS utilization, suggesting that expanding access to primary and behavioral health services could reduce unnecessary low-acuity EMS use.
This qualitative interview study of thirteen Swedish emergency medical dispatchers reveals that prioritizing patients under capacity constraints is an active process of "stewarding scarce response capacity," involving the dynamic balancing of individual clinical urgency, geographic coverage, and population-level readiness through anticipation, reassessment, and collaboration.